Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism

Fatty Livers Induced by Orotic Acid

Rats fed a purified diet supplemented with erotic acid (1%) have gross alterations in their lipid metabolism that can be essentially nullified by further supplementation of the diet with adenine sulfate (0.25%), as described in the first paper of this series (1). Accompanying these changes are certain alterations in the metabolism of pyrimidine derivatives, which have been described in an earli...

Fatty Acid Modification of Mononuclear Cells

Fatty Acid Modification of Mononuclear Cells

Fenofibrate prevents orotic acid--induced hepatic steatosis in rats.

The experiments performed in this report were designed to investigate the mechanisms involved in the metabolic alterations associated with orotic acid-induced hepatic steatosis and the effect of fenofibrate, a stimulant of peroxisome proliferators-activated receptor alpha (PPARalpha), on these alterations. Male Wistar rats were divided into three experimental groups: 1) fed a balanced diet (C);...

Dietary Adenine Alleviates Fatty Liver Induced by Orotic Acid

The effects of dietary adenine in fatty liver induced by orotic acid (OA) were studied. Rats were paired-fed 1% OA-supplemented diets with/or without 0.25% adenine or a diet without OA for 10 days. Serum lipid profiles were measured using enzyme assay kits. Lipids of liver tissues were extracted and liver lipid contents were determined. A peach of liver was prepared to determine the activities ...